PD-L1 expression and patient outcomes in gastrointestinal neuroendocrine neoplasm: a meta-analysis

Role of PD-L1 expression as a biomarker for GEP neuroendocrine neoplasm grading

Neuroendocrine neoplasms (NENs) are rare, heterogeneous and ubiquitous tumors commonly localized in the gastrointestinal tract, lung, and pancreas. The clinical behavior of NEN is highly unpredictable; in fact, low-grade cases can unexpectedly be associated with metastases. Currently, the 2010 WHO NEN classification employs histological differentiation and the proliferation index for grading tu...

Over-Expression of Immunosuppressive Molecules, PD-L1 and PD-L2, in Ulcerative Colitis Patients

PD-L1 and Survival in Solid Tumors: A Meta-Analysis

BACKGROUND Numerous agents targeting PD-L1/PD-1 check-point are in clinical development. However, the correlation between PD-L1 expression and prognosis of solid tumor is still in controversial. Here, we elicit a systematic review and meta-analysis to investigate the potential value of PD-L1 in the prognostic prediction in human solid tumors. METHODS Electronic databases were searched for stu...

Prognostic value of PD-L1 and PD-1 expression in pulmonary neuroendocrine tumors

PURPOSE Programmed death 1 (PD-1) receptor and its ligand, programmed death ligand-1 (PD-L1), play critical roles in the immune invasion of various tumors. This study aimed to explore the clinical significance of PD-L1/PD-1 expression in the progression of pulmonary neuroendocrine tumors (PNETs). METHODS The expression of PD-L1 and PD-1 in 80 patients diagnosed with PNETs were investigated. I...

Expression of PD-L1 and prognosis in breast cancer: a meta-analysis

The associations between programmed cell death ligand 1 (PD-L1) and the prognosis of various cancers have always been a research topic of considerable interest. However, the prognostic value of PD-L1 in breast cancer patients remains a controversial subject. We aimed to assess the association between PD-L1 protein expression and clinicopathological features and the impact of this relationship o...